Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas
More about Open Access at the CrickAuthors list
Anna De Grassi Fabio Iannelli Matteo Cereda Sara Volorio Valentina Melocchi Alessandra Viel Gianluca Basso Luigi Laghi Michele Caselle Francesca CiccarelliAbstract
Mismatch repair deficient colorectal adenomas are composed of transformed cells that descend from a common founder and progressively accumulate genomic alterations. The proliferation history of these tumors is still largely unknown. Here we present a novel approach to rebuild the proliferation trees that recapitulate the history of individual colorectal adenomas by mapping the progressive acquisition of somatic point mutations during tumor growth.
Full text links
Publisher website (DOI) 10.1186/s13059-014-0437-8
Europe PubMed Central 25175524
Pubmed 25175524
Keywords
Type of publication