Dendritic cell lineage potential in human early hematopoietic progenitors
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Julie Helft Fernando Dos Anjos Afonso Annemarthe G van der Veen Probir Chakravarty Dominique Bonnet Caetano Reis e SousaAbstract
Conventional dendritic cells (cDCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). However, a mouse lymphoid-primed multipotent progenitor has been shown to generate cDCs following a DC-specific developmental pathway independent of monocyte and granulocyte poiesis. Similarly, here we show that, in humans, a large fraction of multipotent lymphoid early progenitors (MLPs) gives rise to cDCs, in particular the subset known as cDC1, identified by co-expression of DNGR-1 (CLEC9A) and CD141 (BDCA-3). Single-cell analysis indicates that over one-third of MLPs have the potential to efficiently generate cDCs. cDC1s generated from CMPs or MLPs do not exhibit differences in transcriptome or phenotype. These results demonstrate an early imprinting of the cDC lineage in human hematopoiesis and highlight the plasticity of developmental pathways giving rise to human DCs.
Journal details
Journal Cell Reports
Volume 20
Issue number 3
Pages 529-537
Available online
Publication date
Full text links
Publisher website (DOI) 10.1016/j.celrep.2017.06.075
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Europe PubMed Central 28723558
Pubmed 28723558