Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapyMore about Open Access at the Crick
Authors listChloe I Bloom Christine Graham Matthew PR Berry Katalin Wilkinson Tolu Oni Fotini Rozakeas Zhaohui Xu Jose Rossello-Urgell Damien Chaussabel Jacques Banchereau Virginia Pascual Marc Lipman Robert Wilkinson Anne O'Garra
Globally there are approximately 9 million new active tuberculosis cases and 1.4 million deaths annually. Effective antituberculosis treatment monitoring is difficult as there are no existing biomarkers of poor adherence or inadequate treatment earlier than 2 months after treatment initiation. Inadequate treatment leads to worsening disease, disease transmission and drug resistance.