Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy
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Chloe I Bloom Christine Graham Matthew PR Berry Katalin Wilkinson Tolu Oni Fotini Rozakeas Zhaohui Xu Jose Rossello-Urgell Damien Chaussabel Jacques Banchereau Virginia Pascual Marc Lipman Robert Wilkinson Anne O'GarraAbstract
Globally there are approximately 9 million new active tuberculosis cases and 1.4 million deaths annually. Effective antituberculosis treatment monitoring is difficult as there are no existing biomarkers of poor adherence or inadequate treatment earlier than 2 months after treatment initiation. Inadequate treatment leads to worsening disease, disease transmission and drug resistance.
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Publisher website (DOI) 10.1371/journal.pone.0046191
Europe PubMed Central 23056259
Pubmed 23056259
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