Development of high affinity broadly reactive aptamers for spike protein of multiple SARS-CoV-2 variants

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We have developed broadly reactive aptamers against multiple variants by alternating the target between spike proteins from different SARS-CoV-2 variants during the selection process. In this process we have developed aptamers which can recognise all variants, from the original wild-type 'Wuhan' strain to Omicron, with high affinity (Kd values in the pM range).

Journal details

Volume 13
Issue number 22
Pages 15322-15326
Available online
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