Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

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Authors list

Benjamin N Atkinson David Steadman Yuguang Zhao James Sipthorp Luca Vecchia Reinis R Ruza Fiona Jeganathan Georgie Lines Sarah Frew Amy Monaghan Svend Kjaer Magda Bictash E Yvonne Jones Paul V Fish
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Abstract

Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.

Journal details

Journal MedChemComm
Volume 10
Issue number 8
Pages 1361-1369
Available online
Publication date

Full text links

Publisher website (DOI) 10.1039/c9md00096h
Europe PubMed Central 31534655
Pubmed 31534655

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