Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

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Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.

Journal details

Journal MedChemComm
Volume 10
Issue number 8
Pages 1361-1369
Available online
Publication date


Crick labs/facilities

Acknowledged team

Crick authors

Crick First author
Crick Corresponding author