Discovery of lipid-mediated protein–protein interactions in living cells using metabolic labeling with photoactivatable clickable probes

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Abstract

Metabolic labelling of a specific post-translational modification in cells with a bifunctional probe enables site-specific photocrosslinking, enrichment and identification of PTM-mediated protein–protein interactions through quantitative proteomics.

Journal details

Volume 14
Issue number 9
Pages 2419-2430
Available online
Publication date