DNA fragility and repair: some personal recollections

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In this autobiographical article, I reflect on my Swedish background. Then I discuss endogenous DNA alterations and the base excision repair pathway and alternative repair strategies for some unusual DNA lesions. Endogenous DNA damage, such as loss of purine bases and cytosine deamination, is proposed as a major source of cancer-causing mutations.

Journal details

Volume 92
Pages 1-13
Available online
Publication date


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Crick labs/facilities

Crick authors

Crick First author
Crick Corresponding author