DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

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Authors list

Nnennaya Kanu Maria Antonietta Cerone Gerald Goh Lykourgos-Panagiotis Zalmas Jirina Bartkova Michelle Dietzen Nicholas McGranahan Rebecca Rogers Emily K Law Irina Gromova Maik Kschischo Michael I Walton Olivia W Rossanese Jiri Bartek Reuben S Harris Mani Venkatesan Charles Swanton
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Abstract

The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation. In this study, we sought to identify a molecular basis for APOBEC3 expression and activation.

Journal details

Journal Genome Biology
Volume 17
Issue number 1
Pages 185
Available online
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Publisher website (DOI) 10.1186/s13059-016-1042-9
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Europe PubMed Central 27634334
Pubmed 27634334

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