DNA replication stress mediates APOBEC3 family mutagenesis in breast cancerMore about Open Access at the Crick
Authors listNnennaya Kanu Maria Antonietta Cerone Gerald Goh Lykourgos-Panagiotis Zalmas Jirina Bartkova Michelle Dietzen Nicholas McGranahan Rebecca Rogers Emily K Law Irina Gromova Maik Kschischo Michael I Walton Olivia W Rossanese Jiri Bartek Reuben S Harris Subramanian Venkatesan Charles Swanton
The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation. In this study, we sought to identify a molecular basis for APOBEC3 expression and activation.
Journal Genome Biology
Issue number 1