Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases

Authors list

Naomi F Walker Simon O Clark Tolu Oni Nuria Andreu Liku Tezera Shivani Singh Luísa Saraiva Bernadette Pedersen Dominic L Kelly Julia A Tree Jeanine M D'Armiento Graeme Meintjes Francesco A Mauri Ann Williams Robert Wilkinson Jon S Friedland Paul T Elkington
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Abstract

Tuberculosis kills more than 1.5 million people per year, and standard treatment has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix metalloproteinase (MMP) activity to cause immunopathology. In advanced HIV infection, tissue destruction is reduced, but underlying mechanisms are poorly defined and no current antituberculous therapy reduces host tissue damage.

Journal details

Journal American Journal of Respiratory and Critical Care Medicine
Volume 185
Issue number 9
Pages 989-997
Publication date

Full text links

Publisher website (DOI) 10.1164/rccm.201110-1769OC
Europe PubMed Central 22345579
Pubmed 22345579

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