Efficient high-throughput sequencing of a laser microdissected chromosome arm
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Eva Seifertova Lyle B Zimmerman Michael J Gilchrist Jaroslav Macha Svatava Kubickova Halina Cernohorska Vojtech Zarsky Nick Dl Owens Abdul K Sesay Tereza Tlapakova Vladimir KrylovAbstract
Genomic sequence assemblies are key tools for a broad range of gene function and evolutionary studies. The diploid amphibian Xenopus tropicalis plays a pivotal role in these fields due to its combination of experimental flexibility, diploid genome, and early-branching tetrapod taxonomic position, having diverged from the amniote lineage ~360 million years ago. A genome assembly and a genetic linkage map have recently been made available. Unfortunately, large gaps in the linkage map attenuate long-range integrity of the genome assembly.
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Publisher website (DOI) 10.1186/1471-2164-14-357
Europe PubMed Central 23714049
Pubmed 23714049
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