Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in miceMore about Open Access at the Crick
Authors listAndrea C Bohrer Ehydel Castro Zhidong Hu Artur TL Queiroz Claire E Tocheny Maike Assmann Shunsuke Sakai Christine Nelson Paul J Baker Hui Ma Lin Wang Wen Zilu Elsa du Bruyn Catherine Riou Keith D Kauffman Tuberculosis Imaging Program Ian N Moore Franca Del Nonno Linda Petrone Delia Goletti Adrian R Martineau David M Lowe Mark R Cronan Robert Wilkinson Clifton E Barry Laura E Via Daniel L Barber Amy D Klion Bruno B Andrade Yanzheng Song Ka-Wing Wong Katrin D Mayer-Barber
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Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
Journal Journal of Experimental Medicine
Issue number 10