Epigenetic noise fuels cancer evolution


Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.

Journal details

Journal Cancer Cell
Volume 26
Issue number 6
Pages 775-776
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Type of publication