Epigenetic noise fuels cancer evolution
Abstract
Cancer is a disease of the genome and the epigenome. Previous studies have shown that genomic changes such as mutations, copy number variation, and genomic rearrangements drive cancer evolution. In this issue of Cancer Cell, Landau and colleagues add epigenomic changes, specifically locally disordered DNA methylation, to cancer's evolutionary trajectory.
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Publisher website (DOI) 10.1016/j.ccell.2014.11.003
Europe PubMed Central 25490439
Pubmed 25490439
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