EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease

Abstract

We demonstrate for the first time that EROS (CYBC1/C17ORF62) regulates abundance of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase in human cells and that EROS mutations are a novel cause of chronic granulomatous disease.

Journal details

Volume 143
Issue number 2
Pages 782-785.e1
Available online
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