Escorting client proteins to the Hsp90 molecular chaperone
The co-chaperone complex R2TP assists Hsp90 in the folding and maturation of client proteins such as phosphatidylinositol-3-kinase-like kinases. In this issue of Structure, Rivera-Calzada, Pal et al. (2017) describe the architecture and catalytic properties of R2TP, providing new insights into the interplay between Hsp90 and its co-chaperones.
Issue number 7