Evaluating the significance of density, localization, and PD-1/PD-L1 immunopositivity of mononuclear cells in the clinical course of lung adenocarcinoma patients with brain metastasisMore about Open Access at the Crick
Authors listVanda Téglási Lilla Reiniger Katalin Fábián Orsolya Pipek Irén Csala Attila G Bagó Péter Várallyai Laura Vízkeleti Lívia Rojkó József Tímár Balázs Döme Zoltán Szállási Charles Swanton Judit Moldvay
Management of lung cancer patients who suffer from brain metastases represents a major challenge. Considering the promising results with immune checkpoint inhibitor treatment, evaluating the status of immune cell (IC) infiltrates in the prognosis of brain metastasis may lead to better therapeutic strategies with these agents. The aim of this study was to characterize the distribution of ICs and determine the expression of the checkpoint molecules programmed death protein 1 (PD-1) and its ligand, PD-L1, in brain metastasis of lung adenocarcinoma (LUAD) patients and to analyze their clinicopathological correlations.
Issue number 8