Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial
Authors listM Jamal-Hanjani R A'Hern Nicolai Birkbak P Gorman Eva Gronroos S Ngang P Nicola L Rahman E Thanopoulou Gavin Kelly P Ellis P Barrett-Lee SRD Johnston J Bliss R Roylance Charles Swanton
Chromosomal instability (CIN) has been shown to be associated with drug resistance and poor clinical outcome in several cancer types. However, in oestrogen receptor (ER)-negative breast cancer we have previously demonstrated that extreme CIN is associated with improved clinical outcome, consistent with a negative impact of CIN on tumour fitness and growth. The aim of this current study was to validate this finding using previously defined CIN thresholds in a much larger prospective cohort from a randomised, controlled, clinical trial.
Journal Annals of Oncology
Issue number 7