Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases
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Claire T Deakin Georgina H Cornish Kevin Ng Nikhil Faulkner William Bolland Joshua Hope Annachiara Rosa Ruth Harvey Saira Hussain Chris Earl Bethany R Jebson Meredyth GLL Wilkinson Lucy R Marshall Kathryn O’Brien Elizabeth C Rosser Anna Radziszewska Hannah Peckham Harsita Patel Judith Heaney Hannah Rickman Stavroula Paraskevopoulou Catherine F Houlihan Moira J Spyer Steve Gamblin John Mccauley Eleni Nastouli Michael Levin Peter Cherepanov Coziana Ciurtin Lucy R Wedderburn George Kassiotis Toggle all authors (31)
Abstract
Differences in humoral immunity to coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), between children and adults remain unexplained, and the effect of underlying immune dysfunction or suppression is unknown. Here, we sought to examine the antibody immune competence of children and adolescents with prevalent inflammatory rheumatic diseases, juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM), and juvenile systemic lupus erythematosus (JSLE) against the seasonal human coronavirus (HCoV)-OC43 that frequently infects this age group.
Journal details
Journal Med
Volume 2
Issue number 9
Pages 1093-1109.e6
Available online
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Publisher website (DOI) 10.1016/j.medj.2021.08.001
Europe PubMed Central 34414384
Pubmed 34414384
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