Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation
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Shahryar Kiaii Andrew J Clear Alan G Ramsay Derek Davies Ajanthah Sangaralingam Abigail Lee Maria Calaminici Donna S Neuberg John G GribbenAbstract
Previous studies have demonstrated the prognostic importance of the immune microenvironment in follicular lymphoma (FL). To investigate the molecular mechanisms during which tumor-infiltrating T cells (TILs) are altered in the FL microenvironment, we studied highly purified CD4 and CD8 TILs from lymph node biopsies at diagnosis in treatment-naive patients with FL compared with reactive tonsils and the peripheral blood of healthy donors.
Journal details
Journal Journal of Clinical Oncology
Volume 31
Issue number 21
Pages 2654-2661
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Publisher website (DOI) 10.1200/jco.2012.44.2137
Europe PubMed Central 23775959
Pubmed 23775959
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