Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation

More about Open Access at the Crick

Abstract

Previous studies have demonstrated the prognostic importance of the immune microenvironment in follicular lymphoma (FL). To investigate the molecular mechanisms during which tumor-infiltrating T cells (TILs) are altered in the FL microenvironment, we studied highly purified CD4 and CD8 TILs from lymph node biopsies at diagnosis in treatment-naive patients with FL compared with reactive tonsils and the peripheral blood of healthy donors.

Journal details

Volume 31
Issue number 21
Pages 2654-2661
Publication date

Keywords

Crick labs/facilities