Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation

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Abstract

Previous studies have demonstrated the prognostic importance of the immune microenvironment in follicular lymphoma (FL). To investigate the molecular mechanisms during which tumor-infiltrating T cells (TILs) are altered in the FL microenvironment, we studied highly purified CD4 and CD8 TILs from lymph node biopsies at diagnosis in treatment-naive patients with FL compared with reactive tonsils and the peripheral blood of healthy donors.

Journal details

Volume 31
Issue number 21
Pages 2654-2661
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Crick First author
Crick Corresponding author