Freeing yeast from alcohol addiction (just) to make (it) fat instead
Authors listKiran R Patil Markus Ralser
Synthetically re-designing eukaryotic metabolism has proven immensely challenging, raising the question of whether evolution has metabolically hardwired eukaryotic cells. Yu et al. now report that, through orchestrating multiple genetic changes and laboratory evolution, Saccharomyces metabolism can be reprogrammed from its evolutionary objective of producing ethanol to produce large amounts of free fatty acids.
Issue number 6
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Publisher website (DOI) 10.1016/j.cell.2018.08.024
Europe PubMed Central 30193107
Type of publication