Genetic redundancy, functional compensation, and cancer vulnerability
Authors listMatteo Cereda Thanos P Mourikis Francesca Ciccarelli
Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.