Genetic redundancy, functional compensation, and cancer vulnerability
Abstract
Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.
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Publisher website (DOI) 10.1016/j.trecan.2016.03.003
Europe PubMed Central 28741568
Pubmed 28741568
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