Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene clusterMore about Open Access at the Crick
Authors listAdam D Hargreaves Long Zhou Josef Christensen Ferdinand Marlétaz Shiping Liu Fang Li Peter Gildsig Jansen Enrico Spiga Matilde Thye Hansen Signe Vendelbo Horn Pedersen Shameek Biswas Kyle Serikawa Brian A Fox William R Taylor John Frederick Mulley Guojie Zhang R Scott Heller Peter WH Holland
The sand rat is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene The sequence of sand rat has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.
Issue number 29