Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts
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Helen Pemberton Emma Anderton Harshil Patel Sharon Brookes Hollie Chandler Richard Palermo Julie Stock Marc Rodriguez-Niedenführ Tomas Racek Lucas de Breed Aengus Stewart Nik Matthews Gordon PetersAbstract
Polycomb group proteins form multicomponent complexes that are important for establishing lineage-specific patterns of gene expression. Mammalian cells encode multiple permutations of the prototypic Polycomb repressive complex 1 (PRC1) with little evidence for functional specialization. An aim of this study is to determine whether the multiple orthologs that are co-expressed in human fibroblasts act on different target genes and whether their genomic location changes during cellular senescence.
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Publisher website (DOI) 10.1186/gb-2014-15-2-r23
Europe PubMed Central 24485159
Pubmed 24485159
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