Genomically humanized mice: technologies and promises
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Anny Devoy Rosie KA Bunton-Stasyshyn Victor Tybulewicz Andrew JH Smith Elizabeth MC FisherAbstract
Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success.
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Journal Nature Reviews Genetics
Volume 13
Issue number 1
Pages 14-20
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