Getting to the heart of an unusual kinetochore

More about Open Access at the Crick


The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. Two recent studies provide new structural insights into the formation of this complex, and highlight some intriguing adaptations found in the Drosophila kinetochore.

Journal details

Journal Open Biology
Volume 6
Issue number 4
Pages 160040
Publication date

Crick labs/facilities