Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome
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Francesco Favero Nicholas McGranahan Maximilian Salm Nicolai Birkbak J Zachary Sanborn Stephen C Benz Jennifer Becq John F Peden Zoya Kingsbury Russell J Grocok Sean Humphray David Bentley Bradley Spencer-Dene Alice Gutteridge Michael Brada Stupp Roger Pierre-Yves Dietrich Tim Forshew Marco Gerlinger Andrew Rowan Gordon Stamp Aron C Eklund Zoltan Szallasi Charles SwantonAbstract
Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine approaches.
Journal details
Journal Annals of Oncology
Volume 26
Issue number 5
Pages 880-887
Available online
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Publisher website (DOI) 10.1093/annonc/mdv127
Europe PubMed Central 25732040
Pubmed 25732040
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