Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation


A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to promote efficient glycosaminoglycan-dependent endocytosis and direct translocation.

Journal details

Volume 55
Issue number 31
Pages 4566-4569
Publication date


Crick labs/facilities