HIV-1 capsid is involved in post-nuclear entry stepsMore about Open Access at the Crick
Authors listNan-Yu Chen Lihong Zhou Paul J Gane Silvana Opp Neil J Ball Giuseppe Nicastro Madeleine Zufferey Cindy Buffone Jeremy Luban David Selwood Felipe Diaz-Griffero Ian Taylor Ariberto Fassati
HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid mutation confers resistance to C-A1, suggesting that capsid might affect post-nuclear entry steps.