HIV-1 capsid is involved in post-nuclear entry steps
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Nan-Yu Chen Lihong Zhou Paul J Gane Silvana Opp Neil J Ball Giuseppe Nicastro Madeleine Zufferey Cindy Buffone Jeremy Luban David Selwood Felipe Diaz-Griffero Ian Taylor Ariberto FassatiAbstract
HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the nucleus but it is unclear if it has any function. We reported that the antibiotic Coumermycin-A1 (C-A1) inhibits HIV-1 integration and that a capsid mutation confers resistance to C-A1, suggesting that capsid might affect post-nuclear entry steps.
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Publisher website (DOI) 10.1186/s12977-016-0262-0
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Europe PubMed Central 27107820
Pubmed 27107820
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