HIV coinfection is associated with low-fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosisMore about Open Access at the Crick
Authors listChloé Loiseau Daniela Brites Miriam Reinhard Kathrin Zürcher Sonia Borrell Marie Ballif Lukas Fenner Helen Cox Liliana K Rutaihwa Robert J Wilkinson Marcel Yotebieng E Jane Carter Alash'le Abimiku Olivier Marcy Eduardo Gotuzzo Anchalee Avihingsanon Nicola Zetola Basra Doulla Erik C Böttger Matthias Egger Sebastien Gagneux
We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.
Issue number 10