HIV coinfection is associated with low-fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis

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Abstract

We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.

Journal details

Volume 64
Issue number 10
Pages e00782-20
Available online
Publication date

Crick authors

Crick First author
Crick Corresponding author