Hopefully devoted to Q: targeting glutamine addiction in cancer
More about Open Access at the CrickAbstract
Altered cell metabolism enables tumours to sustain their increased energetic and biosynthetic needs. Although tumour metabolism has long been considered a promising discipline in the development of cancer therapeutics, the majority of work has focused on changes in glucose metabolism. However, the complexity of cellular metabolism means that very rarely is an individual metabolite required for a single purpose, and thus understanding the overall metabolic requirements of tumours is vital. Over the past 30 years, increasing evidence has shown that many tumours require glutamine as well as glucose for their proliferation and survival. In this minireview, we explore the complexity of glutamine metabolism in tumour cells, discussing how the overall context of the tumour dictates the requirement for glutamine and how this can affect the design of effective therapeutic strategies.
Journal details
Journal British Journal of Cancer
Volume 116
Issue number 11
Pages 1375-1381
Publication date
Full text links
Publisher website (DOI) 10.1038/bjc.2017.113
Europe PubMed Central 28441384
Pubmed 28441384
Keywords
Related topics
Type of publication