Human mesenchymal stromal cells senesce with exogenous OCT4
Abstract
The identification of mesenchymal stromal cells (MSC) from bone marrow by Friedenstein et al. dates back to 1970, but many questions remain unanswered about the biology of these cells. MSC have a wide clinical application because of their differentiation capacity and immunosuppressive properties. They are capable of self-renewal; however, the mechanism is poorly understood. The embryonic transcription factor Octamer binding transcription factor 4 (Oct4) has been suggested as an indicator of multipotency for mouse MSC. OCT4 has also been studied extensively for its involvement in self-renewal of embryonic stem cells and in cancer cells.
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Publisher website (DOI) 10.3109/14653249.2012.697145
Europe PubMed Central 22746537
Pubmed 22746537
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