Human whole genome sequencing in South AfricaMore about Open Access at the Crick
Authors listBrigitte Glanzmann Tracey Jooste Samira Ghoor Richard Gordon Rizwana Mia Jun Mao Hao Li Patrick Charls Craig Douman Maritha J Kotze Armand V Peeters Glaudina Loots Monika Esser Caroline T Tiemessen Robert Wilkinson Johan Louw Glenda Gray Robin M Warren Marlo Möller Craig Kinnear
The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the whole genome sequences of the first six human DNA samples sequenced and analysed at the South African Medical Research Council's Genomics Centre. We demonstrate that the data obtained is of high quality, with an average sequencing depth of 36.41, and that the output is comparable to data generated internationally on a similar platform. The Genomics Centre creates an environment where African researchers are able to access world class facilities, increasing local capacity to sequence whole genomes as well as store and analyse the data.
Journal Scientific Reports
Issue number 1