IL6-STAT3-HIF signaling and therapeutic response to the angiogenesis inhibitor sunitinib in ovarian clear cell cancer

Authors list

Michael S Anglesio Joshy George Hagen Kulbe Michael Friedlander Danny Rischin Charlotte Lemech Jeremy Power Jermaine Coward Prue A Cowin Colin M House Probir Chakravarty Kylie L Gorringe Ian G Campbell Australian Ovarian Cancer Study Group Aikou Okamoto Michael J Birrer David G Huntsman Anna de Fazio Steve E Kalloger Frances Balkwill C Blake Gilks David D Bowtell

Abstract

Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is generally refractory to platinum-based chemotherapy. We analyze here the most comprehensive gene expression and copy number data sets, to date, to identify potential therapeutic targets of OCCA.

Journal details

Journal Clinical cancer research
Volume 17
Issue number 8
Pages 2538-2548
Publication date

Full text links

Publisher website (DOI) 10.1158/1078-0432.ccr-10-3314
Europe PubMed Central 21343371
Pubmed 21343371

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Type of publication