Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma
Authors list
Richard C Turkington Laura A Knight Jaine K Blayney Maria Secrier Rosalie Douglas Eileen E Parkes Eilis K Sutton Leanne Stevenson Damian McManus Sophia Halliday Andrena M McCavigan Gemma E Logan Steven M Walker Christopher J Steele Juliane Perner Jan Bornschein Shona MacRae Ahmad Miremadi Eamon McCarron Stephen McQuaid Kenneth Arthur Jacqueline A James Martin M Eatock Robert O'Neill Fergus Noble Timothy J Underwood D Paul Harkin Manuel Salto-Tellez Rebecca C Fitzgerald Richard D Kennedy Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group Toggle all authors (31)
Abstract
Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC.
Journal details
Journal Gut
Volume 68
Issue number 11
Pages 1918-1927
Available online
Publication date
Full text links
Publisher website (DOI) 10.1136/gutjnl-2018-317624
Europe PubMed Central 30852560
Pubmed 30852560
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