Influenza hemagglutinin membrane anchorMore about Open Access at the Crick
Authors listDonald Benton Andrea Nans Lesley Calder Jack Turner Ursula Neu Yi Pu Lin Esther Ketelaars Nicole L Kallewaard Davide Corti Antonio Lanzavecchia Steve Gamblin Peter Rosenthal John J Skehel
My lab has a strong record of publications describing the emerging properties of the influenza haemagglutinin (HA) surface protein and its role in infection. In this publication we were able to present a description of the high resolution cryo EM structure of the full-length HA. This structure represented a major development because, for the first time, it includes not just the ectodomain, but also the membrane anchor. This reveals how the HA protein is embedded in the virus membrane and the significance of the flexible linker that connects the membrane anchor to the ectodomain.
Issue number 40