Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection
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Helena Aegerter Justina Kulikauskaite Stefania Crotta Harshil Patel Gavin Kelly Edith M Hessel Matthias Mack Soren Beinke Andreas WackAbstract
Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monocyte-derived alveolar macrophages (AMs) that produce increased interleukin-6. Influenza-induced monocyte-derived AMs have a surface phenotype similar to resident AMs but display a unique functional, transcriptional and epigenetic profile that is distinct from resident AMs. In contrast, influenza-experienced resident AMs remain largely similar to naive AMs. Thus, influenza changes the composition of the AM population to provide prolonged antibacterial protection. Monocyte-derived AMs persist over time but lose their protective profile. Our results help to understand how transient respiratory infections, a common occurrence in human life, can constantly alter lung immunity by contributing monocyte-derived, recruited cells to the AM population.
Journal details
Journal Nature Immunology
Volume 21
Issue number 2
Pages 145-157
Available online
Publication date
Full text links
Publisher website (DOI) 10.1038/s41590-019-0568-x
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Europe PubMed Central 31932810
Pubmed 31932810