Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

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Authors list

Barrie Peck Zachary T Schug Qifeng Zhang Beatrice Dankworth Dylan T Jones Elizabeth Smethurst Rachana Patel Susan Mason Ming Jiang Rebecca Saunders Michael Howell Richard Mitter Bradley Spencer-Dene Gordon Stamp Lynn McGarry Daniel James Emma Shanks Eric O Aboagye Susan E Critchlow Hing Y Leung Adrian L Harris Michael JO Wakelam Eyal Gottlieb Almut Schulze
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Abstract

Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be suitable therapeutic targets.

Journal details

Journal Cancer & Metabolism
Volume 4
Pages 6
Available online
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Publisher website (DOI) 10.1186/s40170-016-0146-8
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Europe PubMed Central 27042297
Pubmed 27042297

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