Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysisMore about Open Access at the Crick
Authors listSamra Turajlic Kevin Litchfield Hang Xu Rachel Rosenthal Nicholas McGranahan James L Reading Yien Ning S Wong Andrew Rowan Nnennaya Kanu Maise Al Bakir Tim Chambers Roberto Salgado Peter Savas Sherene Loi Nicolai Birkbak Laurent Sansregret Martin Gore James Larkin Sergio A Quezada Charles Swanton
The focus of tumour-specific antigen analyses has been on single nucleotide variants (SNVs), with the contribution of small insertions and deletions (indels) less well characterised. We investigated whether the frameshift nature of indel mutations, which create novel open reading frames and a large quantity of mutagenic peptides highly distinct from self, might contribute to the immunogenic phenotype.
Journal Lancet Oncology
Issue number 8