Insights into the design and interpretation of iCLIP experiments
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Nejc Haberman Ina Huppertz Jan Attig Julian König Zhen Wang Christian Hauer Matthias W Hentze Andreas E Kulozik Hervé Le Hir Tomaž Curk Christopher R Sibley Kathi Zarnack Jernej UleAbstract
Ultraviolet (UV) crosslinking and immunoprecipitation (CLIP) identifies the sites on RNAs that are in direct contact with RNA-binding proteins (RBPs). Several variants of CLIP exist, which require different computational approaches for analysis. This variety of approaches can create challenges for a novice user and can hamper insights from multi-study comparisons. Here, we produce data with multiple variants of CLIP and evaluate the data with various computational methods to better understand their suitability.
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Journal Genome Biology
Volume 18
Issue number 1
Pages 7-7
Available online
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Publisher website (DOI) 10.1186/s13059-016-1130-x
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Europe PubMed Central 28093074
Pubmed 28093074
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