Into the fold: advances in understanding aPKC membrane dynamics
More about Open Access at the CrickAbstract
Atypical protein kinase Cs (aPKCs) are part of the PKC family of protein kinases and are atypical because they don't respond to the canonical PKC activators diacylglycerol (DAG) and Ca2+. They are central to the organization of polarized cells and are deregulated in several cancers. aPKC recruitment to the plasma membrane compartment is crucial to their encounter with substrates associated with polarizing functions. However, in contrast with other PKCs, the mechanism by which atypical PKCs are recruited there has remained elusive until recently. Here, we bring aPKC into the fold, summarizing recent reports on the direct recruitment of aPKC to membranes, providing insight into seemingly discrepant findings and integrating them with existing literature.
Journal details
Journal
Biochemical Journal
Volume
480
Issue number
24
Pages
2037-2044
Available online
Publication date
Full text links
Publisher website (DOI)
10.1042/BCJ20230390
Europe PubMed Central
38100320
Pubmed
38100320
