Intracellular niche switching as host subversion strategy of bacterial pathogens
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Numerous bacterial pathogens "confine" themselves within host cells with an intracellular localization as main or exclusive niche. Many of them switch dynamically between a membrane-bound or cytosolic lifestyle. This requires either membrane damage and/or repair of the bacterial-containing compartment. Niche switching has profound consequences on how the host cell recognizes the pathogens in time and space for elimination. Moreover, niche switching impacts how bacteria communicate with host cells to obtain nutrients, and it affects the accessibility to antibiotics. Understanding the local environments and cellular phenotypes that lead to niche switching is critical for developing new host-targeted antimicrobial strategies, and has the potential to shed light into fundamental cellular processes.
Journal details
Journal Current Opinion in Cell Biology
Volume 76
Pages 102081
Available online
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Publisher website (DOI) 10.1016/j.ceb.2022.102081
Europe PubMed Central 35487154
Pubmed 35487154
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