Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
Authors list
Marco Gerlinger Andrew Rowan Stuart Horswell James Larkin David Endesfelder Eva Gronroos Pierre Martinez Nicholas Matthews Aengus Stewart Patrick Tarpey Ignacio Varela Benjamin Phillimore Sharmin Begum Neil McDonald Adam Butler David Jones Keiran Raine Calli Latimer Claudio R Santos Mahrokh Nohadani Aron C Eklund Bradley Spencer-Dene Graham Clark Lisa Pickering Gordon Stamp Martin Gore Zoltan Szallasi Julian Downward P Andrew Futreal Charles Swanton Toggle all authors (30)
Abstract
Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.
Journal details
Journal New England Journal of Medicine
Volume 366
Issue number 10
Pages 883-892
Publication date
Full text links
Publisher website (DOI) 10.1056/NEJMoa1113205
Europe PubMed Central 22397650
Pubmed 22397650
Keywords
Type of publication
