Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

Journal Article: New England Journal of MedicineYear Published: (2012) Volume Number: 366, Article Number: 883-892

Authors

Gerlinger,Marco; Rowan,Andrew J; Horswell,Stuart; Larkin,James; Endesfelder,David; Gronroos,Eva; Martinez,Pierre; Matthews,Nicholas; Stewart,Aengus; Tarpey,Patrick; Varela,Ignacio; Phillimore,Benjamin; Begum,Sharmin; McDonald,Neil Q; Butler,Adam; Jones,David; Raine,Keiran; Latimer,Calli; Santos,Claudio R; Nohadani,Mahrokh; Eklund,Aron C; Spencer-Dene,Bradley; Clark,Graham; Pickering,Lisa; Stamp,Gordon; Gore,Martin; Szallasi,Zoltan; Downward,Julian; Futreal,P Andrew; Swanton,Charles

Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.