Invariant natural killer T-cell dynamics in human immunodeficiency virus- associated tuberculosis
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Naomi F Walker Charles Opondo Graeme Meintjes Nishta Jhilmeet Jon S Friedland Paul T Elkington Robert Wilkinson Katalin WilkinsonAbstract
Tuberculosis (TB) is the leading cause of mortality and morbidity in people living with human immunodeficiency virus (HIV) infection (PLWH). PLWH with TB disease are at risk of the paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) when they commence antiretroviral therapy. However, the pathophysiology is incompletely understood and specific therapy is lacking. We investigated the hypothesis that invariant natural killer T (iNKT) cells contribute to innate immune dysfunction associated with TB-IRIS.
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Journal Clinical Infectious Diseases
Volume 70
Issue number 9
Pages 1865-1874
Available online
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Publisher website (DOI) 10.1093/cid/ciz501
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Europe PubMed Central 31190065
Pubmed 31190065
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