Invariant natural killer T-cell dynamics in human immunodeficiency virus- associated tuberculosis

More about Open Access at the Crick

Abstract

Tuberculosis (TB) is the leading cause of mortality and morbidity in people living with human immunodeficiency virus (HIV) infection (PLWH). PLWH with TB disease are at risk of the paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) when they commence antiretroviral therapy. However, the pathophysiology is incompletely understood and specific therapy is lacking. We investigated the hypothesis that invariant natural killer T (iNKT) cells contribute to innate immune dysfunction associated with TB-IRIS.

Journal details

Volume 70
Issue number 9
Pages 1865-1874
Available online
Publication date