Is JmjC oxygenase catalysis limited to demethylation?
Authors list
Richard J Hopkinson Louise Walport Martin Münzel Nathan R Rose Tristan J Smart Akane Kawamura Timothy DW Claridge Christopher J SchofieldAbstract
Jobs on the side: Substrate selectivity studies indicate that members of the biomedically important JmjC demethylase family of histone N(ε)-methyllysine demethylases are capable of catalyzing the de-N-alkylation of groups other than N-methyl and can catalyze reactions that form stable hydroxylated products. The differences in binding preferences in this set of enzymes may be helpful in the design of selective inhibitors.
Journal details
Volume 52
Issue number 30
Pages 7709-7713
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Publisher website (DOI) 10.1002/anie.201303282
Europe PubMed Central 23788451
Pubmed 23788451
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