Lessons in conformational signalling: non-catalytic functions of protein kinase C isozymes

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Angus Cameron Mathias Cobbaut Veronique Calleja Neil McDonald Peter Parker
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Abstract

There is a growing literature describing non-catalytic functions of active protein kinases, reflecting the importance of these properties in the kinase repertoire. Here, we discuss recent work in this area relating to the kinase activity-independent oncogenic action of protein kinase C (PKC) alpha and draw parallels in relation with another PKC family member. We go on to illustrate some of the challenges in unpicking these non-catalytic properties with reference to the wider kinome, illustrating the issue that the wrong loss-of-function mutation may mislead. Finally, we comment on the opportunities these deeper insights bring. This article is part of the discussion meeting issue 'Epidermal growth factor receptor after 40 years'.

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Journal Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Volume 381
Issue number 1957
Pages 20240496
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Publisher website (DOI) 10.1098/rstb.2024.0496
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Europe PubMed Central 42656143
Pubmed 42656143

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