Localised interventions in cellular processes
Abstract
The once linear view of cell regulatory processes is now changing as we begin to overlay spatial and temporal characteristics onto signalling pathways and dynamic membranous events. To better understand the properties of these spatially restricted processes we must refine our targeting of these events with acute localised manipulations. We review here the diverse application of a dimerisation system, which exploits immunosuppressor/immunophilin biology to provide a route to drug-inducible subdomain interventions. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases (2012).
Journal details
Journal Biochimica et Biophysica Acta
Volume 1834
Issue number 7
Pages 1364-1370
Publication date
Full text links
Publisher website (DOI) 10.1016/j.bbapap.2013.01.044
Europe PubMed Central 23403146
Pubmed 23403146
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Type of publication