Looping in on splicing: CRIC-seq uncovers PTBP1's long-range RNA regulatory rules
Authors listIra Alexandra Iosub Tajda Klobučar Jernej Ule
RNA looping adds crucial information to understanding the position-dependent regulatory mechanisms of protein-RNA interactions. In this issue, Xue et al.1 present CRIC-seq, which comprehensively identifies RNA loops mediated by specific proteins and demonstrates their value for interpreting disease-causing mutations.
Journal Molecular Cell
Issue number 8