MANIFEST: Multiomic platform for cancer immunotherapy

Authors list

Jonathan Lim Zayd Tippu Pippa G Corrie Michael Hubank James Larkin Trevor D Lawley Mark Stares Grant D Stewart Amy Strange Stefan N Symeonides Bernadett Szabados Nicholas C Turner Tom Waddell Santiago Zelenay Manuel Salto-Tellez Caroline Dive Samra Turajlic MANIFEST consortium
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Abstract

Immunotherapy has revolutionized survival outcomes for many patients diagnosed with cancer. However, biomarkers that can reliably distinguish treatment responders from nonresponders, predict potential life-threatening and life-changing drug-induced toxicities, or rationalize treatment choices are still lacking. In response to this unmet clinical need, we introduce Multiomic ANalysis of Immunotherapy Features Evidencing Success and Toxicity, a tumor type-agnostic platform to provide deep profiling of patients receiving immunotherapy that will enable integrative identification of biomarkers and discovery of novel targets using artificial intelligence and machine learning.

Journal details

Journal Cancer Discovery
Volume 15
Issue number 5
Pages 878-883
Available online
Publication date

Full text links

Publisher website (DOI) 10.1158/2159-8290.CD-25-0099
Europe PubMed Central 40313120
Pubmed 40313120

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