Mechanisms and mechanics of cell competition in epithelia
Abstract
When fast-growing cells are confronted with slow-growing cells in a mosaic tissue, the slow-growing cells are often progressively eliminated by apoptosis through a process known as cell competition. The underlying signalling pathways remain unknown, but recent findings have shown that cell crowding within an epithelium leads to the eviction of cells from the epithelial sheet. This suggests that mechanical forces could contribute to cell elimination during cell competition.
Journal details
Volume 14
Issue number 9
Pages 581-591
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Full text links
Publisher website (DOI) 10.1038/nrm3639
Europe PubMed Central 23942450
Pubmed 23942450
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