Metabolic remodeling in times of stress: who shoots faster than his shadow?


A sudden increase in pentose phosphate pathway (PPP) activity, the fastest known cellular response to oxidative stress, protects cells through timely generation of NADPH. Originally discovered in budding yeast, Kuehne and colleagues demonstrate the conservation of this mechanism in human cells and reveal its importance for skin cells exposed to UV light.

Journal details

Journal Molecular Cell
Volume 59
Issue number 4
Pages 519-521
Publication date