MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms

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EB Amankwatia P Chakravarty FA Carey S Weidlich RJC Steele AJ Munro CR Wolf G Smith

Abstract

Colorectal cancers arise from benign adenomas, although not all adenomas progress to cancer and there are marked interpatient differences in disease progression. We have previously associated KRAS mutations with disease progression and reduced survival in colorectal cancer patients.

Journal details

Journal British Journal of Cancer
Volume 112
Issue number 9
Pages 1480-1490
Publication date

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Publisher website (DOI) 10.1038/bjc.2015.125
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Europe PubMed Central 25919696
Pubmed 25919696

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